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Rapid kinetic analysis of multichannel records by a simultaneous fit to all dwell-time histograms.

A method is presented for rapidly extracting single-channel transition rate constants from patch-clamp recordings containing signals from several channels. The procedure is based on a simultaneous fit of the observed dwell-time distributions for all conductance levels, using a maximum likelihood app...

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Bibliographic Details
Main Author: Csanády, L
Format: Artigo
Language:Inglês
Published: 2000
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1300681/
https://ncbi.nlm.nih.gov/pubmed/10653791
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