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Mice with chronic norepinephrine deficiency resemble amphetamine-sensitized animals

Acute pharmacological blockade of α1 adrenoreceptors (ARs) attenuates the locomotor response to amphetamine (LRA). We took a genetic approach to study how norepinephrine (NE) signaling modulates psychostimulant responses by testing LRA in dopamine β-hydroxylase knockout (Dbh−/−) mice that lack NE. S...

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Autori principali: Weinshenker, David, Miller, Nicole S., Blizinsky, Katherine, Laughlin, Marc L., Palmiter, Richard D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC129790/
https://ncbi.nlm.nih.gov/pubmed/12370425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212519999
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