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Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins

Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by loss of spinal motor neurons. The gene encoding the survival of motor neurons (SMN) protein is mutated in >95% of SMA cases. SMN is the central component of a large oligomeric complex, including Gemins2–7, that is neces...

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Détails bibliographiques
Auteurs principaux: Shpargel, Karl B., Matera, A. Gregory
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2005
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1297697/
https://ncbi.nlm.nih.gov/pubmed/16301532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508947102
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