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An activation domain in the C-terminal subunit of HCF-1 is important for transactivation by VP16 and LZIP

In herpes simplex virus, lytic replication is initiated by the viral transactivator VP16 acting with cellular cofactors Oct-1 and HCF-1. Although this activator complex has been studied in detail, the role of HCF-1 remains elusive. Here, we show that HCF-1 contains an activation domain (HCF-1(AD)) r...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Luciano, Randy L., Wilson, Angus C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129685/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12271126/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.202200399
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