Nerve growth factor controls GAP-43 mRNA stability via the phosphoprotein ARPP-19

The membrane phosphoprotein GAP-43 is involved in axon growth and synaptic plasticity. In PC12 pheochromocytoma cells, induction of a neuronal phenotype by nerve growth factor (NGF) is accompanied by a marked increase in GAP-43 levels. NGF regulates GAP-43 expression by altering the half-life of its...

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Bibliografiska uppgifter
Huvudupphovsmän: Irwin, Nina, Chao, Steven, Goritchenko, Luda, Horiuchi, Atsuko, Greengard, Paul, Nairn, Angus C., Benowitz, Larry I.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2002
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC129461/
https://ncbi.nlm.nih.gov/pubmed/12221279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.152457399
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