Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

The serine-threonine kinase Akt seems to be central in mediating stimuli from different classes of receptors. In fact, both IGF-1 and IL6-like cytokines induce hypertrophic and antiapoptotic signals in cardiomyocytes through PI3K-dependent Akt activation. More recently, it was shown that Akt is invo...

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Hlavní autoři: Condorelli, Gianluigi, Drusco, Alessandra, Stassi, Giorgio, Bellacosa, Alfonso, Roncarati, Roberta, Iaccarino, Guido, Russo, Matteo A., Gu, Yusu, Dalton, Nancy, Chung, Clarence, Latronico, Michael V. G., Napoli, Claudio, Sadoshima, Junichi, Croce, Carlo M., Ross, John
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2002
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC129445/
https://ncbi.nlm.nih.gov/pubmed/12237475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.172376399
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