Using mechanical force to probe the mechanism of pausing and arrest during continuous elongation by Escherichia coli RNA polymerase

Escherichia coli RNA polymerase translocates along the DNA discontinuously during the elongation phase of transcription, spending proportionally more time at some template positions, known as pause and arrest sites, than at others. Current models of elongation suggest that the enzyme backtracks at t...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Forde, Nancy R., Izhaky, David, Woodcock, Glenna R., Wuite, Gijs J. L., Bustamante, Carlos
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2002
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129329/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12193647/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.142417799
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