P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-α and promotes hyperplasia in mammary epithelium

Stimulation of p21-activated kinase-1 (Pak1) induces cytoskeleton reorganization and signaling pathways in mammary cancer cells. Here, we show that inhibition of Pak1 kinase activity by a dominant-negative fragment or by short interference RNA markedly reduced the estrogen receptor-α (ER) transactiv...

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Main Authors: Wang, Rui-An, Mazumdar, Abhijit, Vadlamudi, Ratna K., Kumar, Rakesh
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2002
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC129075/
https://ncbi.nlm.nih.gov/pubmed/12374744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf543
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