Interaction between mevalonate pathway and retinoic acid-induced differentiation

All trans retinoic acid (ATRA) is a potent inducer of differentiation of HL-60 cell line. The pretreatment of the cells by compactin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl (HMG) CoA reductase, during 24 hours, enhances the ATRA-induced cell differentiation. At 50 nM, the percentage o...

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Main Authors: Gueddari-Pouzols, Naima, Duriez, Patrick, Chomienne, Christine, Trussardi, Aurélie, Jardillier, Jean Claude
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2001
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC129055/
https://ncbi.nlm.nih.gov/pubmed/12488603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/S1110724301000183
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