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Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors

Matrix metalloproteinase (MMP)-1, MMP-8 and MMP-13 are interstitial collagenases that degrade type II collagen in cartilage; this is a committed step in the progression of rheumatoid arthritis and osteoarthritis. Of these enzymes, the expression of MMP-1 and MMP-13 is substantially increased in resp...

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Bibliographic Details
Main Authors: Vincenti, Matthew P, Brinckerhoff, Constance E
Format: Artigo
Language:Inglês
Published: BioMed Central 2002
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC128926/
https://ncbi.nlm.nih.gov/pubmed/12010565
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