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A Coalescent Approach to Study Linkage Disequilibrium between Single-Nucleotide Polymorphisms

We present the results of extensive simulations that emulate the development and distribution of linkage disequilibrium (LD) between single-nucleotide polymorphisms (SNPs) and a gene locus that is phenotypically stratified into two classes (disease phenotype and wild-type phenotype). Our approach, b...

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Main Authors: Zöllner, Sebastian, von Haeseler, Arndt
格式: Artigo
語言:Inglês
出版: The American Society of Human Genetics 2000
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1288114/
https://ncbi.nlm.nih.gov/pubmed/10677321
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