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MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function

MicroRNAs (miRNAs) repress translation of target mRNAs by interaction with partially mismatched sequences in their 3′ UTR. The mechanism by which they act on translation has remained largely obscure. We examined the translation of mRNAs containing four partially mismatched miRNA-binding sites in the...

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Detalhes bibliográficos
Main Authors: Humphreys, David T., Westman, Belinda J., Martin, David I. K., Preiss, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1287990/
https://ncbi.nlm.nih.gov/pubmed/16287976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506482102
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