Multicolor FISH Analysis of Chromosomal Breaks, Duplications, Deletions, and Numerical Abnormalities in the Sperm of Healthy Men

Transmitted de novo structural chromosomal abnormalities, the majority of which are paternally derived, can lead to abnormal reproductive outcomes as well as genetic diseases in offspring. We developed and validated a new multicolor FISH procedure (sperm ACM, which utilizes DNA probes specific for t...

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Main Authors: Sloter, Eddie D., Lowe, Xiu, Moore II, Dan H., Nath, Joginder, Wyrobek, Andrew J.
Format: Artigo
Jezik:Inglês
Izdano: The American Society of Human Genetics 2000
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1287891/
https://ncbi.nlm.nih.gov/pubmed/10961911
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