Activation of p21-Activated Kinase 2 by Human Immunodeficiency Virus Type 1 Nef Induces Merlin Phosphorylation

The accessory human immunodeficiency virus type 1 (HIV-1) protein Nef activates the autophosphorylation activity of p21-activated kinase 2 (PAK2). Merlin, a cellular substrate of PAK2, is homologous to the ezrin-radixin-moesin family and plays a critical role in Rac signaling. To assess the possible...

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Detalhes bibliográficos
Main Authors: Wei, Bangdong L., Arora, Vivek K., Raney, Alexa, Kuo, Lillian S., Xiao, Guang-Hui, O'Neill, Eduardo, Testa, Joseph R., Foster, John L., Garcia, J. Victor
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1287594/
https://ncbi.nlm.nih.gov/pubmed/16282498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.23.14976-14980.2005
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