Mycothiol-Deficient Mycobacterium smegmatis Mutants Are Hypersensitive to Alkylating Agents, Free Radicals, and Antibiotics

Mycothiol (MSH; 1d-myo-inosityl 2-[N-acetyl-l-cysteinyl]amido-2-deoxy-α-d-glucopyranoside) is the major low-molecular-weight thiol produced by mycobacteria. Mutants of Mycobacterium smegmatis mc(2)155 deficient in MSH production were produced by chemical mutagenesis as well as by transposon mutagene...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Rawat, Mamta, Newton, Gerald L., Ko, Mary, Martinez, Gladys J., Fahey, Robert C., Av-Gay, Yossef
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2002
Témata:	Susceptibility
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC128700/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12384335/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.11.3348-3355.2002
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