Attenuated Salmonella enterica Serovar Typhi Expressing Urease Effectively Immunizes Mice against Helicobacter pylori Challenge as Part of a Heterologous Mucosal Priming-Parenteral Boosting Vaccination Regimen

Recombinant vaccine strains of Salmonella enterica serovar Typhi capable of expressing Helicobacter pylori urease were generated by transforming strains CVD908 and CVD908-htrA with a plasmid harboring the ureAB genes under the control of an in vivo-inducible promoter. The plasmid did not interfere w...

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Autors principals: Londoño-Arcila, Patricia, Freeman, Donna, Kleanthous, Harry, O'Dowd, Aisling M., Lewis, Susan, Turner, Arthur K., Rees, Emma L., Tibbitts, Timothy J., Greenwood, Judith, Monath, Thomas P., Darsley, Michael J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Microbial Immunity and Vaccines
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC128259/
https://ncbi.nlm.nih.gov/pubmed/12183559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.9.5096-5106.2002
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