Characterization of Salmonella enterica Derivatives Harboring Defined aroC and Salmonella Pathogenicity Island 2 Type III Secretion System (ssaV) Mutations by Immunization of Healthy Volunteers

The attenuation and immunogenicity of two novel Salmonella vaccine strains, Salmonella enterica serovar Typhi (Ty2 ΔaroC ΔssaV, designated ZH9) and S. enterica serovar Typhimurium (TML ΔaroC ΔssaV, designated WT05), were evaluated after their oral administration to volunteers as single escalating do...

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Detalhes bibliográficos
Main Authors: Hindle, Zoë, Chatfield, Steven N., Phillimore, Jo, Bentley, Matthew, Johnson, Julie, Cosgrove, Catherine A., Ghaem-Maghami, Marjan, Sexton, Amy, Khan, Mohammad, Brennan, Frank R., Everest, Paul, Wu, Tao, Pickard, Derek, Holden, David W., Dougan, Gordon, Griffin, George E., House, Deborah, Santangelo, Joseph D., Khan, Shahid A., Shea, Jaqueline E., Feldman, Robert G., Lewis, David J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC128087/
https://ncbi.nlm.nih.gov/pubmed/12065485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.7.3457-3467.2002
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