Proteolysis of CD14 on Human Gingival Fibroblasts by Arginine-Specific Cysteine Proteinases from Porphyromonas gingivalis Leading to Down-Regulation of Lipopolysaccharide-Induced Interleukin-8 Production

Arginine-specific cysteine proteinases (gingipains-R) from periodontopathic Porphyromonas gingivalis cleaved CD14, a bacterial pattern recognition receptor, on human gingival fibroblasts (HGF). Consequently, gingipains-R reduced lipopolysaccharide-induced interleukin-8 production by HGF, indicating...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Tada, Hiroyuki, Sugawara, Shunji, Nemoto, Eiji, Takahashi, Nobuhiro, Imamura, Takahisa, Potempa, Jan, Travis, James, Shimauchi, Hidetoshi, Takada, Haruhiko
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Host Response and Inflammation
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127988/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12011031/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.6.3304-3307.2002
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