Proteolysis of CD14 on Human Gingival Fibroblasts by Arginine-Specific Cysteine Proteinases from Porphyromonas gingivalis Leading to Down-Regulation of Lipopolysaccharide-Induced Interleukin-8 Production

Arginine-specific cysteine proteinases (gingipains-R) from periodontopathic Porphyromonas gingivalis cleaved CD14, a bacterial pattern recognition receptor, on human gingival fibroblasts (HGF). Consequently, gingipains-R reduced lipopolysaccharide-induced interleukin-8 production by HGF, indicating...

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Hlavní autoři: Tada, Hiroyuki, Sugawara, Shunji, Nemoto, Eiji, Takahashi, Nobuhiro, Imamura, Takahisa, Potempa, Jan, Travis, James, Shimauchi, Hidetoshi, Takada, Haruhiko
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2002
Témata:
Host Response and Inflammation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC127988/
https://ncbi.nlm.nih.gov/pubmed/12011031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.6.3304-3307.2002
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