In Vivo Clearance of an Intracellular Bacterium, Francisella tularensis LVS, Is Dependent on the p40 Subunit of Interleukin-12 (IL-12) but Not on IL-12 p70

To determine the role of interleukin-12 (IL-12) in primary and secondary immunity to a model intracellular bacterium, we have comprehensively evaluated infection with Francisella tularensis LVS in three murine models of IL-12 deficiency. Mice lacking the p40 protein of IL-12 (p40 knockout [KO] mice)...

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Détails bibliographiques
Auteurs principaux: Elkins, Karen L., Cooper, Allison, Colombini, Susan M., Cowley, Siobhán C., Kieffer, Tara L.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2002
Sujets:
Bacterial Infections
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC127864/
https://ncbi.nlm.nih.gov/pubmed/11895957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.4.1936-1948.2002
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