Disruption of the Candida albicans TPS2 Gene Encoding Trehalose-6-Phosphate Phosphatase Decreases Infectivity without Affecting Hypha Formation

Deletion of trehalose-6-phosphate phosphatase, encoded by TPS2, in Saccharomyces cerevisiae results in accumulation of trehalose-6-phosphate (Tre6P) instead of trehalose under stress conditions. Since trehalose is an important stress protectant and Tre6P accumulation is toxic, we have investigated w...

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Bibliographische Detailangaben
Hauptverfasser: Van Dijck, Patrick, De Rop, Larissa, Szlufcik, Karolina, Van Ael, Elke, Thevelein, Johan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Fungal and Parasitic Infections
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC127825/
https://ncbi.nlm.nih.gov/pubmed/11895938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.4.1772-1782.2002
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