Construction and Characterization of a Live, Attenuated aroA Deletion Mutant of Pseudomonas aeruginosa as a Candidate Intranasal Vaccine

Antibodies to the lipopolysaccharide O antigen of Pseudomonas aeruginosa mediate high-level immunity, but protective epitopes have proven to be poorly immunogenic, while nonprotective or minimally protective O-antigen epitopes often elicit the best immune responses. With the goal of developing a bro...

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Autors principals: Priebe, Gregory P., Brinig, Mary M., Hatano, Kazue, Grout, Martha, Coleman, Fadie T., Pier, Gerald B., Goldberg, Joanna B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Microbial Immunity and Vaccines
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC127764/
https://ncbi.nlm.nih.gov/pubmed/11854239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.3.1507-1517.2002
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