Deletion of the Two-Component Histidine Kinase Gene (CHK1) of Candida albicans Contributes to Enhanced Growth Inhibition and Killing by Human Neutrophils In Vitro

We have observed that human neutrophils (polymorphonuclear leukocytes [PMNs]) have an increased growth-inhibitory and killing effect on a strain of Candida albicans with a deletion of CHK1, a gene encoding a putative histidine kinase. The PMN effect was not due to increased phagocytosis of the null...

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Main Authors: Torosantucci, Antonella, Chiani, Paola, De Bernardis, Flavia, Cassone, Antonio, Calera, Jose Antonio, Calderone, Richard
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2002
Teme:
Fungal and Parasitic Infections
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC127696/
https://ncbi.nlm.nih.gov/pubmed/11796636
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