Deletion of the Two-Component Histidine Kinase Gene (CHK1) of Candida albicans Contributes to Enhanced Growth Inhibition and Killing by Human Neutrophils In Vitro

We have observed that human neutrophils (polymorphonuclear leukocytes [PMNs]) have an increased growth-inhibitory and killing effect on a strain of Candida albicans with a deletion of CHK1, a gene encoding a putative histidine kinase. The PMN effect was not due to increased phagocytosis of the null...

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Bibliografiske detaljer

Udgivet i:	Infect Immun
Principais autores:	Torosantucci, Antonella, Chiani, Paola, De Bernardis, Flavia, Cassone, Antonio, Calera, Jose Antonio, Calderone, Richard
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2002
Fag:	Fungal and Parasitic Infections
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127696/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11796636/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.70.2.985-987.2002
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