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N-glycans of core2 β(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of α(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin binding

C2GnT-I [core2 β(1,6)-N-acetyglucosaminyltransferase-I] and FucT-VII [α(1,3)-fucosyltransferase-VII] are the key enzymes for the biosynthesis of sialyl-Lewis x determinants on selectin ligands and therefore they represent good drug targets for the treatment of inflammatory disorders and other pathol...

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Autors principals: Prorok-Hamon, Maëlle, Notel, Frédéric, Mathieu, Sylvie, Langlet, Claire, Fukuda, Minoru, El-Battari, Assou
Format: Artigo
Idioma:Inglês
Publicat: Portland Press Ltd. 2005
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276950/
https://ncbi.nlm.nih.gov/pubmed/15926890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050344
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