Mutations in ponA, the Gene Encoding Penicillin-Binding Protein 1, and a Novel Locus, penC, Are Required for High-Level Chromosomally Mediated Penicillin Resistance in Neisseria gonorrhoeae

Chromosomally mediated penicillin resistance in Neisseria gonorrhoeae occurs in part through alterations in penicillin-binding proteins (PBPs) and a decrease in outer membrane permeability. However, the genetic and molecular mechanisms of transformation of a penicillin-susceptible strain of N. gonor...

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Main Authors: Ropp, Patricia A., Hu, Mei, Olesky, Melanie, Nicholas, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
Assuntos:
Mechanisms of Resistance
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC127492/
https://ncbi.nlm.nih.gov/pubmed/11850260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.3.769-777.2002
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