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Mutant TEM β-Lactamase Producing Resistance to Ceftazidime, Ampicillins, and β-Lactamase Inhibitors

A derivative of the TEM-1 β-lactamase producing clinically significant levels of resistance to ceftazidime and β-lactamase inhibitors in the presence of penicillins was generated following five rounds of DNA shuffling and selection. This complex mutant enzyme contained three amino acid substitutions...

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Bibliografski detalji
Glavni autori: Vakulenko, Sergei, Golemi, Dasantila
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2002
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC127477/
https://ncbi.nlm.nih.gov/pubmed/11850243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.3.646-653.2002
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