Phenylpropenamide Derivatives AT-61 and AT-130 Inhibit Replication of Wild-Type and Lamivudine-Resistant Strains of Hepatitis B Virus In Vitro

The phenylpropenamide derivatives AT-61 and AT-130 are nonnucleoside analogue inhibitors of hepatitis B virus (HBV) replication. They inhibited the replication of wild-type HBV with 50% inhibitory concentrations of 21.2 ± 9.5 and 2.40 ± 0.92 μM, respectively, compared to 0.064 ± 0.020 μM lamivudine....

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Delaney IV, William E., Edwards, Ros, Colledge, Danni, Shaw, Tim, Furman, Phil, Painter, George, Locarnini, Stephen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127422/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12183271/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.9.3057-3060.2002
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