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Heterologous Expression of Epothilone Biosynthetic Genes in Myxococcus xanthus
Epothilones are potential anticancer drugs that stabilize microtubules in a manner similar to paclitaxel (Taxol). Epothilones are produced from the myxobacterium Sorangium cellulosum, which has a 16-h doubling time and produces only milligram-per-liter amounts of epothilone A and epothilone B. Furth...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC127399/ https://ncbi.nlm.nih.gov/pubmed/12183227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.9.2772-2778.2002 |
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