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Analysis of a Heme-Dependent Signal Transduction System in Corynebacterium diphtheriae: Deletion of the chrAS Genes Results in Heme Sensitivity and Diminished Heme-Dependent Activation of the hmuO Promoter

The Corynebacterium diphtheriae hmuO gene encodes a heme oxygenase that is involved in the utilization of heme as an iron source. Transcription of hmuO is activated by heme or hemoglobin and repressed by iron and DtxR. Previous studies with Escherichia coli showed that heme-dependent transcriptional...

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Detalhes bibliográficos
Main Authors: Bibb, Lori A., King, Natalie D., Kunkle, Carey A., Schmitt, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1273899/
https://ncbi.nlm.nih.gov/pubmed/16239540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.11.7406-7412.2005
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