Molecular Characterization of Recombinant Pneumocystis carinii Topoisomerase I: Differential Interactions with Human Topoisomerase I Poisons and Pentamidine

The Pneumocystis carinii topoisomerase I-encoding gene has been cloned and sequenced, and the expressed enzyme interactions with several classes of topoisomerase I poisons have been characterized. The P. carinii topoisomerase I protein contains 763 amino acids and has a molecular mass of ca. 90 kDa....

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Van Dross, Rukiyah T., Sanders, Marilyn M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Mechanisms of Action: Physiological Effects
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127280/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12069967/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.7.2145-2154.2002
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