Pharmacology of β-l-Thymidine and β-l-2′-Deoxycytidine in HepG2 Cells and Primary Human Hepatocytes: Relevance to Chemotherapeutic Efficacy against Hepatitis B Virus

β-l-Thymidine (l-dT) and β-l-2′-deoxycytidine (l-dC) are potent and highly specific inhibitors of hepatitis B virus (HBV) replication both in vivo and in vitro (50% effective concentrations, 0.19 to 0.24 μM in 2.2.15 cells). The intracellular metabolisms of l-dT and l-dC were investigated in HepG2 c...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Hernandez-Santiago, B., Placidi, L., Cretton-Scott, E., Faraj, A., Bridges, E. G., Bryant, M. L., Rodriguez-Orengo, J., Imbach, J. L., Gosselin, G., Pierra, C., Dukhan, D., Sommadossi, J. P.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Antiviral Agents
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127241/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12019082/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.6.1728-1733.2002
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