Efficacy of β-Lactams for Treating Experimentally Induced Pneumonia Due to a Carbapenem-Hydrolyzing Metallo-β-Lactamase-Producing Strain of Pseudomonas aeruginosa

A rat pneumonia model was established with a Pseudomonas aeruginosa strain that produced the plasmid-encoded metallocarbapenemase VIM-2. A significant decrease in lung bacterial titers was observed when imipenem, cefepime, ceftazidime, and piperacillin-tazobactam were given at the highest doses reco...

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Bibliographische Detailangaben
Hauptverfasser: Bellais, Samuel, Mimoz, Olivier, Léotard, Sophie, Jacolot, Anne, Petitjean, Olivier, Nordmann, Patrice
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC127240/
https://ncbi.nlm.nih.gov/pubmed/12019134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.6.2032-2034.2002
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