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Effects of Amino Acid Alterations in Penicillin-Binding Proteins (PBPs) 1a, 2b, and 2x on PBP Affinities of Penicillin, Ampicillin, Amoxicillin, Cefditoren, Cefuroxime, Cefprozil, and Cefaclor in 18 Clinical Isolates of Penicillin-Susceptible, -Intermediate, and -Resistant Pneumococci

Amino acid alterations in or flanking conserved motifs making up the active binding sites of penicillin-binding proteins (PBPs) 1a, 2b, and 2x of pneumococci were correlated with changes in affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor for these P...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Nagai, Kensuke, Davies, Todd A., Jacobs, Michael R., Appelbaum, Peter C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2002
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127189/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11959556/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.5.1273-1280.2002
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