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Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA
Communication between U1 and U2 snRNPs is critical during pre-spliceosome assembly; yet, direct connections have not been observed. To investigate this assembly step, we focused on Prp5, an RNA-dependent ATPase of the DExD/H family. We identified homologs of Saccharomyces cerevisiae Prp5 in humans (...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2004
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1271757/ https://ncbi.nlm.nih.gov/pubmed/14713954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600050 |
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