Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA

Communication between U1 and U2 snRNPs is critical during pre-spliceosome assembly; yet, direct connections have not been observed. To investigate this assembly step, we focused on Prp5, an RNA-dependent ATPase of the DExD/H family. We identified homologs of Saccharomyces cerevisiae Prp5 in humans (...

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Huvudupphovsmän: Xu, Yong-Zhen, Newnham, Catherine M, Kameoka, Sei, Huang, Tao, Konarska, Maria M, Query, Charles C
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2004
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1271757/
https://ncbi.nlm.nih.gov/pubmed/14713954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600050
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