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Recruitment of Cdc28 by Whi3 restricts nuclear accumulation of the G1 cyclin–Cdk complex to late G1

The G1 cyclin Cln3 is a key activator of cell-cycle entry in budding yeast. Here we show that Whi3, a negative G1 regulator of Cln3, interacts in vivo with the cyclin-dependent kinase Cdc28 and regulates its localization in the cell. Efficient interaction with Cdc28 depends on an N-terminal domain o...

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Bibliografske podrobnosti
Main Authors: Wang, Hongyin, Garí, Eloi, Vergés, Emili, Gallego, Carme, Aldea, Martí
Format: Artigo
Jezik:Inglês
Izdano: 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1271660/
https://ncbi.nlm.nih.gov/pubmed/14685274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600022
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