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Kinetic Analysis of Wild-Type and YMDD Mutant Hepatitis B Virus Polymerases and Effects of Deoxyribonucleotide Concentrations on Polymerase Activity

Mutations in the YMDD motif of the hepatitis B virus (HBV) DNA polymerase result in reduced susceptibility of HBV to inhibition by lamivudine, at a cost in replication fitness. The mechanisms underlying the effects of YMDD mutations on replication fitness were investigated using both a cell-based vi...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Gaillard, Richard K., Barnard, Jennifer, Lopez, Vincent, Hodges, Paula, Bourne, Eric, Johnson, Lance, Allen, Marchelle I., Condreay, Patrick, Miller, Wayne H., Condreay, Lynn D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2002
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127103/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11897582/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.4.1005-1013.2002
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