Kinetic Analysis of Wild-Type and YMDD Mutant Hepatitis B Virus Polymerases and Effects of Deoxyribonucleotide Concentrations on Polymerase Activity

Mutations in the YMDD motif of the hepatitis B virus (HBV) DNA polymerase result in reduced susceptibility of HBV to inhibition by lamivudine, at a cost in replication fitness. The mechanisms underlying the effects of YMDD mutations on replication fitness were investigated using both a cell-based vi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Gaillard, Richard K., Barnard, Jennifer, Lopez, Vincent, Hodges, Paula, Bourne, Eric, Johnson, Lance, Allen, Marchelle I., Condreay, Patrick, Miller, Wayne H., Condreay, Lynn D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127103/
https://ncbi.nlm.nih.gov/pubmed/11897582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.4.1005-1013.2002
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados