Evaluation of a Cyclic GMP-Dependent Protein Kinase Inhibitor in Treatment of Murine Toxoplasmosis: Gamma Interferon Is Required for Efficacy

The trisubstituted pyrrole 4-[2-(4-fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl]pyridine (compound 1) is a potent inhibitor of cyclic GMP-dependent protein kinases from Apicomplexan protozoa and displays cytostatic activity against Toxoplasma gondii in vitro. Compound 1 has now been eval...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Nare, Bakela, Allocco, John J., Liberator, Paul A., Donald, Robert G. K.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Experimental Therapeutics
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127074/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11796334/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.2.300-307.2002
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