Prediction of Abacavir Resistance from Genotypic Data: Impact of Zidovudine and Lamivudine Resistance In Vitro and In Vivo

Abacavir is frequently used in antiretroviral combination therapies as a potent nucleoside reverse transcriptase inhibitor (NRTI). Four mutations are selected for by abacavir in vitro and in vivo: K65R, L74V, Y115F, and M184V. Abacavir resistance has also been observed in NRTI multidrug-resistant sa...

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Bibliographic Details
Main Authors: Walter, Hauke, Schmidt, Barbara, Werwein, Marianne, Schwingel, Eva, Korn, Klaus
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC126991/
https://ncbi.nlm.nih.gov/pubmed/11751116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.1.89-94.2002
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