Pharmacodynamics of Gatifloxacin against Streptococcus pneumoniae in an In Vitro Pharmacokinetic Model: Impact of Area under the Curve/MIC Ratios on Eradication

Previous studies have demonstrated that fluoroquinolone area under the curve (AUC)/MIC ratios of 30 to 50 are sufficient to eradicate pneumococci from in vitro pharmacokinetic models (IVPMs). However, more systematic studies of the impact of AUC/MIC ratios on the antipneumococcal activities of fluor...

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Bibliographic Details
Main Author: Lister, Philip D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC126977/
https://ncbi.nlm.nih.gov/pubmed/11751113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.1.69-74.2002
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