mda-7 (IL-24) mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK

Subtraction hybridization identified melanoma differentiation-associated gene-7 (mda-7) as a gene induced during terminal differentiation in human melanoma cells. On the basis of structure, chromosomal localization and cytokine-like properties, mda-7 is classified as IL-24. Administration of mda-7/I...

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Detalhes bibliográficos
Main Authors: Sarkar, Devanand, Su, Zao-Zhong, Lebedeva, Irina V., Sauane, Moira, Gopalkrishnan, Rahul V., Valerie, Kristoffer, Dent, Paul, Fisher, Paul B.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC126623/
https://ncbi.nlm.nih.gov/pubmed/12114539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.152327199
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