Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands

A number of poorly characterized genetic modifiers contribute to the extensive variability of von Willebrand disease, the most prevalent bleeding disorder in humans. We find that a genetic lesion inactivating the murine ST3Gal-IV sialyltransferase causes a bleeding disorder associated with an autoso...

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Autori principali: Ellies, Lesley G., Ditto, David, Levy, Gallia G., Wahrenbrock, Mark, Ginsburg, David, Varki, Ajit, Le, Dzung T., Marth, Jamey D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2002
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC126621/
https://ncbi.nlm.nih.gov/pubmed/12097641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.142005099
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