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Role of the E1A Rb-binding domain in repression of the NF-κB-dependent defense against tumor necrosis factor-α

The adenoviral E1A oncogene sensitizes mammalian cells to tumor necrosis factor-α (TNF-α), in part by repressing the nuclear factor-κ B (NF-κB)-dependent defense against this cytokine. Other E1A activities involve binding to either p300/cyclic AMP response element-binding protein (CBP) or retinoblas...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Cook, James L., Walker, Thomas A., Worthen, G. Scott, Radke, Jay R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126608/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12119420/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.162082999
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