Intracellular Screen To Identify Metagenomic Clones That Induce or Inhibit a Quorum-Sensing Biosensor

The goal of this study was to design and evaluate a rapid screen to identify metagenomic clones that produce biologically active small molecules. We built metagenomic libraries with DNA from soil on the floodplain of the Tanana River in Alaska. We extracted DNA directly from the soil and cloned it i...

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Bibliografiske detaljer
Main Authors: Williamson, Lynn L., Borlee, Bradley R., Schloss, Patrick D., Guan, Changhui, Allen, Heather K., Handelsman, Jo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Microbial Ecology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265936/
https://ncbi.nlm.nih.gov/pubmed/16204555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.71.10.6335-6344.2005
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