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Endoplasmic Reticulum Stress Accelerates p53 Degradation by the Cooperative Actions of Hdm2 and Glycogen Synthase Kinase 3β

Inactivation of the tumor suppressor p53 by degradation is a mechanism utilized by cells to adapt to endoplasmic reticulum (ER) stress. However, the mechanisms of p53 destabilization by ER stress are not known. We demonstrate here that the E3 ubiquitin-ligase Hdm2 is essential for the nucleocytoplas...

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Библиографические подробности
Главные авторы: Pluquet, Olivier, Qu, Li-Ke, Baltzis, Dionissios, Koromilas, Antonis E.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2005
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265800/
https://ncbi.nlm.nih.gov/pubmed/16227590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.21.9392-9405.2005
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