Mutually Exclusive Subsets of BH3-Only Proteins Are Activated by the p53 and c-Jun N-Terminal Kinase/c-Jun Signaling Pathways during Cortical Neuron Apoptosis Induced by Arsenite

The c-Jun N-terminal protein kinase (JNK)/c-Jun and p53 pathways form distinct death-signaling modules in neurons that culminate in Bax-dependent apoptosis. To investigate whether this signaling autonomy is due to recruitment of particular BH3-only proteins, we searched for a toxic signal that would...

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Detalhes bibliográficos
Main Authors: Wong, Hon Kit, Fricker, Michael, Wyttenbach, Andreas, Villunger, Andreas, Michalak, Ewa M., Strasser, Andreas, Tolkovsky, Aviva M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265744/
https://ncbi.nlm.nih.gov/pubmed/16166651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.19.8732-8747.2005
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