Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling

Drosophila Sprouty (dSpry) was genetically identified as a novel antagonist of fibroblast growth factor receptor (FGFR), epidermal growth factor receptor (EGFR) and Sevenless signalling, ostensibly by eliciting its response on the Ras/MAPK pathway. Four mammalian sprouty genes have been cloned, whic...

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Главные авторы: Wong, Esther Sook Miin, Fong, Chee Wai, Lim, Jormay, Yusoff, Permeen, Low, Boon Chuan, Langdon, Wallace Y., Guy, Graeme R.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2002
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC126289/
https://ncbi.nlm.nih.gov/pubmed/12234920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf493
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