Reduced Secretion of Virions and Hepatitis B Virus (HBV) Surface Antigen of a Naturally Occurring HBV Variant Correlates with the Accumulation of the Small S Envelope Protein in the Endoplasmic Reticulum and Golgi Apparatus

We identified two novel naturally occurring mutations (W74L and L77R) in the small S envelope protein of hepatitis B virus (HBV). Mutation L77R alone resulted in >10-fold-reduced secretion of virions. In addition, the 2.8-fold reduction of the extracellular HBV surface antigen (HBsAg) of mutant L...

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Detalhes bibliográficos
Main Authors: Chua, Pong Kian, Wang, Robert Yung-Liang, Lin, Min-Hui, Masuda, Tetsuya, Suk, Fat-Moon, Shih, Chiaho
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1262590/
https://ncbi.nlm.nih.gov/pubmed/16227269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.21.13483-13496.2005
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