Prophylactic Alpha Interferon Treatment Increases the Therapeutic Index of Oncolytic Vesicular Stomatitis Virus Virotherapy for Advanced Hepatocellular Carcinoma in Immune-Competent Rats

Vesicular stomatitis virus (VSV) is a negative-strand RNA virus with intrinsic oncolytic specificity due to substantially attenuated antiviral responses in many tumors. We have recently reported that recombinant VSV vector can be used as an effective oncolytic agent to safely treat multifocal hepato...

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Bibliographic Details
Main Authors: Shinozaki, Katsunori, Ebert, Oliver, Suriawinata, Arief, Thung, Swan N., Woo, Savio L. C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Gene Delivery
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1262571/
https://ncbi.nlm.nih.gov/pubmed/16227290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.21.13705-13713.2005
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