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Profound effect of normalization on detection of differentially expressed genes in oligonucleotide microarray data analysis

BACKGROUND: Oligonucleotide microarrays measure the relative transcript abundance of thousands of mRNAs in parallel. A large number of procedures for normalization and detection of differentially expressed genes have been proposed. However, the relative impact of these methods on the detection of di...

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Autors principals: Hoffmann, Reinhard, Seidl, Thomas, Dugas, Martin
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC126238/
https://ncbi.nlm.nih.gov/pubmed/12184807
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