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Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8

The involvement of the death adaptor protein FADD and the apoptosis-initiating caspase-8 in CD95 and TRAIL death signalling has recently been demonstrated by the analysis of the native death-inducing signalling complex (DISC) that forms upon ligand-induced receptor cross-linking. However, the role o...

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Udgivet i:EMBO J
Principais autores: Sprick, Martin R., Rieser, Eva, Stahl, Heiko, Grosse-Wilde, Anne, Weigand, Markus A., Walczak, Henning
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126181/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12198154/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf441
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