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A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

The cyclin-dependent kinase inhibitor, p27(Kip1), which regulates cell cycle progression, is controlled by its subcellular localization and subsequent degradation. p27(Kip1) is phosphorylated on serine 10 (S10) and threonine 187 (T187). Although the role of T187 and its phosphorylation by Cdks is we...

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Udgivet i:EMBO J
Principais autores: Boehm, Manfred, Yoshimoto, Takanobu, Crook, Martin F., Nallamshetty, Shriram, True, Andrea, Nabel, Gary J., Nabel, Elizabeth G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126092/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12093740/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf343
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